Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in preclinical cardiac safety assessment for ove...

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Bibliographic Details
Main Authors: Xiaoli Tang, Zengwu Wang, Shengshou Hu, Bingying Zhou
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
mitochondria
drug toxicity
cardiomyocyte
high-throughput screening
preclinical cardiac safety assessment
Online Access:https://www.mdpi.com/1999-4923/14/7/1313

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https://www.mdpi.com/1999-4923/14/7/1313

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