Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPyV small tumor (ST) and large tumor (LT) antigens i...

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Bibliographic Details
Main Authors: Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010551

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https://doi.org/10.1371/journal.ppat.1010551

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