Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)

Licorice (Glycyrrhiza uralensis Fisch) is a natural plant resource widely used as a food and herbal medication in China. Glycycoumarin (GCM) is a major coumarin in licorice that possesses several biological activities. However, little is known about its pharmacokinetic profile. The present study aim...

Full description

Bibliographic Details
Main Authors:	Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Series:	Frontiers in Pharmacology
Subjects:	glycycoumarin pharmacokinetics bioavailability tissue distribution LC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1216985/full

Similar Items

Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice
by: Mingzhu Yan, et al.
Published: (2021-08-01)

Tissue Culture and Micropropagation of Mongolian Licorice ( Glycyrrhiza uralensis Fisch.)
by: Yu. Oyunbileg, et al.
Published: (2005-06-01)

Metabolome and transcriptome integration explored the mechanism of browning in Glycyrrhiza uralensis Fisch cells
by: Xinyang Zhao, et al.
Published: (2024-07-01)

Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration
by: Ming-Cong Zheng, et al.
Published: (2022-06-01)

The Pharmacokinetic and Absolute Bioavailability of Cyclosporine (Atopica for Cats<sup>®</sup>) in Cats
by: Jingyuan Kong, et al.
Published: (2023-06-01)

Determination of oleandrin and adynerin in rat plasma by UPLC–MS/MS and their pharmacokinetic study
by: Meiling Zhang, et al.
Published: (2022-12-01)

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings
by: Jie Li, et al.
Published: (2017-06-01)

Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch.
by: Tingting Li, et al.
Published: (2020-01-01)

Research Note: Pharmacokinetics of bromhexine hydrochloride in broilers after single oral and intravenous administration
by: Ming-Hui Duan, et al.
Published: (2024-07-01)

Pharmacokinetics of Nafamostat, a Potent Serine Protease Inhibitor, by a Novel LC-MS/MS Analysis
by: Hyeon Seok Oh, et al.
Published: (2022-03-01)

Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method
by: Lulu Yu, et al.
Published: (2023-07-01)

The complete mitochondrial genome of Glycyrrhiza uralensis Fisch. (Fabales, Leguminosae)
by: Yan-Yun Yang, et al.
Published: (2021-02-01)

Biochar Amendments Improve Licorice (<i>Glycyrrhiza uralensis</i> Fisch.) Growth and Nutrient Uptake under Salt Stress
by: Dilfuza Egamberdieva, et al.
Published: (2021-10-01)

Chondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis
by: Wang P, et al.
Published: (2023-02-01)

Oral Bioavailability Evaluation of Celastrol-Encapsulated Silk Fibroin Nanoparticles Using an Optimized LC-MS/MS Method
by: Shuyu Zhan, et al.
Published: (2020-07-01)

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth
by: Eman A. Alraddadi, et al.
Published: (2018-03-01)

In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides
by: Abudukahaer Wubuli, et al.
Published: (2024-07-01)

Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1<i>H</i>-1,2,4-Triazol-3-ylthio-conjugate of Prottremine
by: Daria S. Gorina, et al.
Published: (2024-09-01)

A Novel UHPLC-MS/MS-Based Bioanalytical Method Developed for S-Allyl Cysteine in the Establishment of a Comparative Pharmacokinetic Study
by: Mohd Faiyaz Khan, et al.
Published: (2023-07-01)

Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study
by: Sreekanth Dittakavi, et al.
Published: (2019-04-01)

Pharmacokinetic analysis and tissue distribution of Vam3 in the rat by a validated LC-MS/MS method
by: Ruixia Zhang, et al.
Published: (2015-05-01)

A Validated HPLC-MS/MS Assay for 14-<i>O</i>-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats
by: Yunxing Fu, et al.
Published: (2019-02-01)

Quantitative Analysis of Flavonoids in Glycyrrhiza uralensis Fisch by 1H-qNMR
by: Ping Yu, et al.
Published: (2021-01-01)

Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch
by: Wenxin Xia, et al.
Published: (2021-01-01)

The impact of salinization on soil bacterial diversity, yield and quality of Glycyrrhiza uralensis Fisch.
by: Yangmei Bao, et al.
Published: (2024-08-01)

The correlation between pharmacological activity and contents of eight constituents of Glycyrrhiza uralensis Fisch
by: Rui He, et al.
Published: (2023-03-01)

Coupling effects of irrigation amount and fertilization rate on growth and bioactive components of four-year-old licorice (Glycyrrhiza uralensis Fisch) in arid regions of Xinjiang
by: Abudukeyoumu Abudurezike, et al.
Published: (2024-10-01)

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model
by: Yawen Yuan, et al.
Published: (2023-01-01)

Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk
by: Shuang Li, et al.
Published: (2024-03-01)

Design and optimization of heat pump with infrared drying for Glycyrrhiza uralensis (Licorice) processing
by: Lichun Zhu, et al.
Published: (2024-05-01)

Tracking the effect of roasting and fermentation on the metabolites of licorice root (Glycyrrhiza glabra L.) using UPLC-MS analysis combined with multivariate statistical analysis
by: Sarah S. Takla, et al.
Published: (2023-11-01)

Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin–Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus
by: Arina G. Nemolochnova, et al.
Published: (2022-09-01)

Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method
by: Zuo Sai-Jie, et al.
Published: (2021-09-01)

Self-Assembled Nanoparticles from Xie-Bai-San Decoction: Isolation, Characterization and Enhancing Oral Bioavailability
by: Nie W, et al.
Published: (2024-04-01)

Pharmacokinetics and brain distribution of the therapeutic peptide liraglutide by a novel LC–MS/MS analysis
by: Hyeon Seok Oh, et al.
Published: (2023-03-01)

The Biological Fate of Pharmaceutical Excipient β-Cyclodextrin: Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism of β-Cyclodextrin in Rats
by: Kunqian Mu, et al.
Published: (2022-02-01)

Hydroalcoholic extract of licorice (Glycyrrhiza glabra L.) root attenuates ethanol and cerulein induced pancreatitis in rats
by: Sarmishta Srikantam, et al.
Published: (2019-01-01)

Enhanced salt tolerance in Glycyrrhiza uralensis Fisch. via Bacillus subtilis inoculation alters microbial community
by: Jiancai Xiao, et al.
Published: (2024-10-01)

Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy
by: Niyaz Ahmad, et al.
Published: (2020-02-01)

Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method
by: Haihua Shang, et al.
Published: (2022-04-01)