AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis

AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis

Summary: Doxorubicin induces myocardial injury and fibrosis. Still, no effective interventions are available. AP39 is an H2S donor that explicitly targets mitochondria. This study investigated whether AP39 could improve doxorubicin-induced myocardial fibrosis. Doxorubicin induced significant myocard...

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Bibliographic Details
Main Authors: Junxiong Zhao, Ting Yang, Jiali Yi, Hongmin Hu, Qi Lai, Liangui Nie, Maojun Liu, Chun Chu, Jun Yang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Health sciences
Toxicology
Toxic substance
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422400542X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422400542X

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