CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannabinoid (eCB)/CB1R system. Here we...

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Bibliographic Details
Main Authors: Adi Drori, Asaad Gammal, Shahar Azar, Liad Hinden, Rivka Hadar, Daniel Wesley, Alina Nemirovski, Gergő Szanda, Maayan Salton, Boaz Tirosh, Joseph Tam
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
endocannabinoids
leptin resistance
ER stress
obesity
cb1 receptor
CHOP
Online Access:https://elifesciences.org/articles/60771

Internet

https://elifesciences.org/articles/60771

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