Cassiaside C Inhibits M1 Polarization of Macrophages by Downregulating Glycolysis

Cassiaside C Inhibits M1 Polarization of Macrophages by Downregulating Glycolysis

Classically activated M1 macrophages reprogram their metabolism towards enhanced glycolysis to obtain energy and produce pro-inflammatory cytokines after activation by mammalian target of rapamycin complex 1 (mTORC1) and hypoxia-inducible factor (HIF)-1α. Thus, a strategy that constrains M1 polariza...

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Bibliographic Details
Main Authors: Ye Jin Kim, Sungwoo Lee, Jonghwa Jin, Hyein Woo, Yeon-Kyung Choi, Keun-Gyu Park
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
M1 polarization
macrophage
glycolysis
Cassiaside C
Online Access:https://www.mdpi.com/1422-0067/23/3/1696

Internet

https://www.mdpi.com/1422-0067/23/3/1696

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