Synthesis, Antimycobacterial, Antifungal and Photosynthesis-Inhibiting Activity of Chlorinated N-phenylpyrazine-2-carboxamides †

Synthesis, Antimycobacterial, Antifungal and Photosynthesis-Inhibiting Activity of Chlorinated N-phenylpyrazine-2-carboxamides †

A series of sixteen pyrazinamide analogues with the -CONH- linker connecting the pyrazine and benzene rings was synthesized by the condensation of chlorides of substituted pyrazinecarboxylic acids with ring-substituted (chlorine) anilines. The prepared compounds were characterized and evaluated for...

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Bibliographic Details
Main Authors: Katarina Kralova, Josef Jampilek, Marcela Vejsova, Jiri Dohnal, Vladimir Buchta, Zdenek Osicka, Jiri Kunes, Jan Zitko, Martin Dolezal
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:Molecules
Subjects:
pyrazinecarboxamides
lipophilicity
in vitro antimycobacterial activity
in vitro antifungal activity
spinach chloroplasts
PET inhibition
structure–activity relationships
Online Access:http://www.mdpi.com/1420-3049/15/12/8567/

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http://www.mdpi.com/1420-3049/15/12/8567/

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