Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation
Abstract To improve the performance of assisted reproductive technology, it is necessary to find an indicator that can identify and select embryos that will be born or be aborted. We searched for indicators of embryo selection by comparing born/abort mouse embryos. We found that asynchronous embryos...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13646-8 |
| _version_ | 1818253169081188352 |
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| author | Daisuke Mashiko Zenki Ikeda Mikiko Tokoro Yu Hatano Tatsuma Yao Tetsuya J. Kobayashi Noritaka Fukunaga Yoshimasa Asada Kazuo Yamagata |
| author_facet | Daisuke Mashiko Zenki Ikeda Mikiko Tokoro Yu Hatano Tatsuma Yao Tetsuya J. Kobayashi Noritaka Fukunaga Yoshimasa Asada Kazuo Yamagata |
| author_sort | Daisuke Mashiko |
| collection | DOAJ |
| description | Abstract To improve the performance of assisted reproductive technology, it is necessary to find an indicator that can identify and select embryos that will be born or be aborted. We searched for indicators of embryo selection by comparing born/abort mouse embryos. We found that asynchronous embryos during the 4–8-cell stage were predisposed to be aborted. In asynchronous mouse embryos, the nuclear translocation of YAP1 in some blastomeres and compaction were delayed, and the number of ICMs was reduced. Hence, it is possible that asynchronous embryos have abnormal differentiation. When the synchrony of human embryos was observed, it was confirmed that embryos that did not reach clinical pregnancy had asynchrony as in mice. This could make synchrony a universal indicator common to all animal species. |
| first_indexed | 2024-12-12T16:35:48Z |
| format | Article |
| id | doaj.art-20e8b91dc96c4515bea4408979d2786d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T16:35:48Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-20e8b91dc96c4515bea4408979d2786d2022-12-22T00:18:40ZengNature PortfolioScientific Reports2045-23222022-06-0112111410.1038/s41598-022-13646-8Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiationDaisuke Mashiko0Zenki Ikeda1Mikiko Tokoro2Yu Hatano3Tatsuma Yao4Tetsuya J. Kobayashi5Noritaka Fukunaga6Yoshimasa Asada7Kazuo Yamagata8Graduate School of Biology-Oriented Science and Technology, Kindai UniversityGraduate School of Biology-Oriented Science and Technology, Kindai UniversityGraduate School of Biology-Oriented Science and Technology, Kindai UniversityGraduate School of Biology-Oriented Science and Technology, Kindai UniversityGraduate School of Biology-Oriented Science and Technology, Kindai UniversityInstitute of Industrial Science, The University of TokyoAsada Institute for Reproductive Medicine, Asada Ladies ClinicAsada Institute for Reproductive Medicine, Asada Ladies ClinicGraduate School of Biology-Oriented Science and Technology, Kindai UniversityAbstract To improve the performance of assisted reproductive technology, it is necessary to find an indicator that can identify and select embryos that will be born or be aborted. We searched for indicators of embryo selection by comparing born/abort mouse embryos. We found that asynchronous embryos during the 4–8-cell stage were predisposed to be aborted. In asynchronous mouse embryos, the nuclear translocation of YAP1 in some blastomeres and compaction were delayed, and the number of ICMs was reduced. Hence, it is possible that asynchronous embryos have abnormal differentiation. When the synchrony of human embryos was observed, it was confirmed that embryos that did not reach clinical pregnancy had asynchrony as in mice. This could make synchrony a universal indicator common to all animal species.https://doi.org/10.1038/s41598-022-13646-8 |
| spellingShingle | Daisuke Mashiko Zenki Ikeda Mikiko Tokoro Yu Hatano Tatsuma Yao Tetsuya J. Kobayashi Noritaka Fukunaga Yoshimasa Asada Kazuo Yamagata Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation Scientific Reports |
| title | Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation |
| title_full | Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation |
| title_fullStr | Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation |
| title_full_unstemmed | Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation |
| title_short | Asynchronous division at 4–8-cell stage of preimplantation embryos affects live birth through ICM/TE differentiation |
| title_sort | asynchronous division at 4 8 cell stage of preimplantation embryos affects live birth through icm te differentiation |
| url | https://doi.org/10.1038/s41598-022-13646-8 |
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