The Novel Pimavanserin Derivative ST-2300 with Histamine H<sub>3</sub> Receptor Affinity Shows Reduced 5-HT<sub>2A</sub> Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice
The therapy of depression is challenging and still unsatisfactory despite the presence of many antidepressant drugs on the market. Consequently, there is a continuous need to search for new, safer, and more effective antidepressant therapeutics. Previous studies have suggested a potential associatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/5/683 |