Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.

Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.

Mutations in GDAP1, which encodes protein located in the mitochondrial outer membrane, cause axonal recessive (AR-CMT2), axonal dominant (CMT2K) and demyelinating recessive (CMT4A) forms of Charcot-Marie-Tooth (CMT) neuropathy. Loss of function recessive mutations in GDAP1 are associated with decrea...

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Bibliographic Details
Main Authors: Manuela Barneo-Muñoz, Paula Juárez, Azahara Civera-Tregón, Laura Yndriago, David Pla-Martin, Jennifer Zenker, Carmen Cuevas-Martín, Anna Estela, María Sánchez-Aragó, Jerónimo Forteza-Vila, José M Cuezva, Roman Chrast, Francesc Palau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4393229?pdf=render

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http://europepmc.org/articles/PMC4393229?pdf=render

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