Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.

Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.

Spinocerebellar ataxia type 17 (SCA17) involves the expression of a polyglutamine (polyQ) expanded TATA-binding protein (TBP), a general transcription initiation factor. TBP interacts with other protein factors, including high mobility group box 1 (HMGB1), to regulate gene expression. Previously, ou...

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Bibliographic Details
Main Authors: Li-Ching Lee, Chiung-Mei Chen, Pin-Rong Wang, Ming-Tsan Su, Guey-Jen Lee-Chen, Chun-Yen Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4280131?pdf=render

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http://europepmc.org/articles/PMC4280131?pdf=render

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