RNF115 Inhibits the Post‐ER Trafficking of TLRs and TLRs‐Mediated Immune Responses by Catalyzing K11‐Linked Ubiquitination of RAB1A and RAB13

RNF115 Inhibits the Post‐ER Trafficking of TLRs and TLRs‐Mediated Immune Responses by Catalyzing K11‐Linked Ubiquitination of RAB1A and RAB13

Abstract The subcellular localization and intracellular trafficking of Toll‐like receptors (TLRs) critically regulate TLRs‐mediated antimicrobial immunity and autoimmunity. Here, it is demonstrated that the E3 ubiquitin ligase RNF115 inhibits the post‐endoplasmic reticulum (ER) trafficking of TLRs a...

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Bibliographic Details
Main Authors: Zhi‐Dong Zhang, Hong‐Xu Li, Hu Gan, Zhen Tang, Yu‐Yao Guo, Shu‐Qi Yao, Tianzi Liuyu, Bo Zhong, Dandan Lin
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
intracellular trafficking
RAB proteins
RNF115
signaling transduction
Toll‐like receptors
ubiquitination
Online Access:https://doi.org/10.1002/advs.202105391

Internet

https://doi.org/10.1002/advs.202105391

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