Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment

Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment

Cholesterol is essential for cell function and viability. It is a component of the plasma membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D. As a ligand for estrogen-related receptor alpha (ESRRA), cholesterol becomes a signaling molecule. Furthermore, chole...

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Bibliographic Details
Main Authors: Adele Chimento, Ivan Casaburi, Paola Avena, Francesca Trotta, Arianna De Luca, Vittoria Rago, Vincenzo Pezzi, Rosa Sirianni
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Endocrinology
Subjects:
cholesterol
statins
cancer treatment
lipid raft
oxysterols
steroids
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00807/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00807/full

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