Normal Thermostability of p.Ser113Leu and p.Arg631Cys Variants of Mitochondrial Carnitine Palmitoyltransferase II (CPT II) in Human Muscle Homogenate

Normal Thermostability of p.Ser113Leu and p.Arg631Cys Variants of Mitochondrial Carnitine Palmitoyltransferase II (CPT II) in Human Muscle Homogenate

Previous fibroblast and recombinant enzyme studies showed a markedly thermolabile p.Ser113Leu variant compared to the wild-type (WT) in muscle carnitine palmitoyltransferase II (CPT II) deficiency. Additionally, it has been shown that cardiolipin (CLP) stimulated or inhibited the p.Ser113Leu recombi...

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Bibliographic Details
Main Authors: Pushpa Raj Joshi, Maria Gräfin zu Stolberg-Stolberg, Leila Motlagh Scholle, Beate Meinhardt, Elena Pegoraro, Stephan Zierz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Metabolites
Subjects:
CPT II
muscle
mitochondria
thermolability
malonyl-CoA
cardiolipin
Online Access:https://www.mdpi.com/2218-1989/12/11/1141

Internet

https://www.mdpi.com/2218-1989/12/11/1141

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