Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators

Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators

Herein, we present the structure-based design, synthesis and biological evaluation of novel mono- and di-carboxylic 3,4-dihydroquinoxalin-2(1H)-one derivatives as potential heme-independent activators of soluble guanylate cyclase (sGC). Docking calculations of several known sGC agonists by utilizing...

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Bibliographic Details
Main Authors: Dionysios-Panagiotis Kintos, Konstantinos Salagiannis, Vasiliki Vazoura, Theresa Wittrien, Athanasios Papakyriakou, Sotiris S. Nikolaropoulos, Soenke Behrends, Stavros Topouzis, Manolis A. Fousteris
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Heliyon
Subjects:
Nitric oxide
Soluble guanylyl cyclase
sGC activators
3,4-Dihydroquinoxalin-2(1H)-one
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022027268

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http://www.sciencedirect.com/science/article/pii/S2405844022027268

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