Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts

Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts

In this study we analyzed whether anti-β2-GPI antibodies from patients with APS induce the endothelial cell expression of Tissue Factor (TF) by a LRP6 signal transduction pathway involving lipid rafts. HUVEC were stimulated with affinity purified anti-β2-GPI antibodies. Both LRP6 and β-catenin phosp...

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Bibliographic Details
Main Authors: Gloria Riitano, Antonella Capozzi, Serena Recalchi, Daniela Caissutti, Agostina Longo, Vincenzo Mattei, Fabrizio Conti, Roberta Misasi, Tina Garofalo, Maurizio Sorice, Valeria Manganelli
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
antiphospholipid syndrome
β2-GPI-glycoprotein I
LRP-6
Tissue Factor
signal transduction
Online Access:https://www.mdpi.com/2073-4409/11/8/1288

Internet

https://www.mdpi.com/2073-4409/11/8/1288

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