Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis

Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis

ABSTRACT Ehrlichia chaffeensis, an obligatory intracellular bacterium, causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. Here, we investigated the vaccine potential of OMP-1B and VirB2-4. Among the highly expressed and immunodominant E....

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Bibliographic Details
Main Authors: Khemraj Budachetri, Mingqun Lin, Rory C. Chien, Wenqing Zhang, Guy Nathaniel Brock, Yasuko Rikihisa
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
Ehrlichia
OMP-1B
VirB2-4
vaccine
dog
tick transmission
Online Access:https://journals.asm.org/doi/10.1128/mbio.02140-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02140-22

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