Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea

Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea

Hair cell (HC) loss is the major cause of permanent sensorineural hearing loss in mammals. Unlike lower vertebrates, mammalian cochlear HCs cannot regenerate spontaneously after damage, although the vestibular system does maintain limited HC regeneration capacity. Thus HC regeneration from the damag...

Full description

Bibliographic Details
Main Authors: Yan Chen, Xiaoling Lu, Luo Guo, Wenli Ni, Yanping Zhang, Liping Zhao, Lingjie Wu, Shan Sun, Shasha Zhang, Mingliang Tang, Wenyan Li, Renjie Chai, Huawei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
inner ear
Hedgehog signaling
hair cell regeneration
Lgr5
proliferation
differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00426/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00426/full

Similar Items