Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions

Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions

Effects of genetic variants on the risk of complex diseases estimated from association studies are typically small. Nonetheless, variants may have important effects in presence of specific levels of environmental exposures, and when a trait related to the disease (endophenotype) is either normal or...

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Bibliographic Details
Main Authors: Alexandre eBureau, Jordie eCroteau, Christian eCouture, Marie-Claude eVohl, Claude eBouchard, Louis ePérusse
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Genetics
Subjects:
metabolic syndrome
physical activity
endophenotype
abdominal obesity
polytomous logistic model
Generalized estimating equations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00248/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00248/full

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