TGF-β1 Drives Inflammatory Th Cell But Not Treg Cell Compartment Upon Allergen Exposure

TGF-β1 Drives Inflammatory Th Cell But Not Treg Cell Compartment Upon Allergen Exposure

TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 and Th17 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance in influencing the outcome of the disease. Here we demonstrat...

Full description

Bibliographic Details
Main Authors: Stephanie Musiol, Francesca Alessandrini, Constanze A. Jakwerth, Adam M. Chaker, Evelyn Schneider, Ferdinand Guerth, Benjamin Schnautz, Johanna Grosch, Ileana Ghiordanescu, Julia T. Ullmann, Josephine Kau, Mirjam Plaschke, Stefan Haak, Thorsten Buch, Carsten B. Schmidt-Weber, Ulrich M. Zissler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
TGF-beta
Th2
Th9
Th17
asthma
allergen-specific immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763243/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.763243/full

Similar Items