GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart

GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart

Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing cardiovascular diseases and heart failure. Therefore...

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Bibliographic Details
Main Authors: Daniela Sorriento, Jessica Gambardella, Antonella Fiordelisi, Guido Iaccarino, Maddalena Illario
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
G protein-coupled receptor kinase 2
β-arrestins
mitochondria
heart failure
cardiac damage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00064/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00064/full

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