The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) represent the largest membrane protein family and a significant target class for therapeutics. Receptors from GPCRs’ largest class, class A, influence virtually every aspect of human physiology. About 45% of the members of this family endogenously bind flexible pe...
Main Authors: | Oanh Vu, Brian Joseph Bender, Lisa Pankewitz, Daniel Huster, Annette G. Beck-Sickinger, Jens Meiler |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/1/210 |
Similar Items
-
Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-like Receptor 1 for Cancer Treatment
by: Tobias F. Fischer, et al.
Published: (2021-07-01) -
Capturing Peptide–GPCR Interactions and Their Dynamics
by: Anette Kaiser, et al.
Published: (2020-10-01) -
Disrupting GPCR Complexes with Smart Drug-like Peptides
by: Maria Gallo, et al.
Published: (2022-01-01) -
GPCR-Based Bioactive Peptide Screening Using Phage-Displayed Peptides and an Insect Cell System for Insecticide Discovery
by: Man-Yeon Choi, et al.
Published: (2021-04-01) -
Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection
by: Fabian Liessmann, et al.
Published: (2023-04-01)