Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

Polymyxin B, produced by Paenibacillus polymyxa, is used as the last line of defense clinically. In this study, exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of P. polymyxa CJX518-AC (PPAC) from 0.15 g/L and 61.8 % t...

Full description

Bibliographic Details
Main Authors: Hui-Zhong Sun, Si-Yu Wei, Qiu-Man Xu, Wei Shang, Qing Li, Jing-Sheng Cheng, Ying-Jin Yuan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Polymyxin
Co-culture
Paenibacillus polymyxa
Corynebacterium glutamicum
Medium optimization
Metabolic precursors
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000152

Internet

http://www.sciencedirect.com/science/article/pii/S2405805X24000152

Similar Items