Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease

Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease

Abstract Objectives Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated disease manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in the pathogenesis of IgG4-RD is still unclear, we conduct this study to investigate epigenet...

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Bibliographic Details
Main Authors: Xunyao Wu, Anqi Wang, Mu Wang, Yu Peng, Yingying Chen, Jieqiong Li, Zheng Liu, Hui Lu, Jiaxin Zhou, Linyi Peng, Yan Zhao, Xiaofeng Zeng, Yunyun Fei, Wen Zhang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Arthritis Research & Therapy
Subjects:
IgG4-RD
DNA methylation
B cells
CD4+ T cells
Salivary gland tissues
Online Access:https://doi.org/10.1186/s13075-022-02978-5

Internet

https://doi.org/10.1186/s13075-022-02978-5

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