Dynamics and quantitative contribution of the aminoglycoside 6′-N-acetyltransferase type Ib to amikacin resistance

Dynamics and quantitative contribution of the aminoglycoside 6′-N-acetyltransferase type Ib to amikacin resistance

ABSTRACTAminoglycosides are essential components in the available armamentarium to treat bacterial infections. The surge and rapid dissemination of resistance genes strongly reduce their efficiency, compromising public health. Among the multitude of modifying enzymes that confer resistance to aminog...

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Bibliographic Details
Main Authors: Ophélie d’Udekem d’Acoz, Fong Hue, Tianyi Ye, Louise Wang, Maxime Leroux, Lucila Rajngewerc, Tung Tran, Kimberly Phan, Maria S. Ramirez, Walter Reisner, Marcelo E. Tolmasky, Rodrigo Reyes-Lamothe
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mSphere
Subjects:
amikacin
antibiotic resistance
fluorescence
AAC(6′)-Ib
Escherichia coli
CRISPRi
Online Access:https://journals.asm.org/doi/10.1128/msphere.00789-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00789-23

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