Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells

Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells

We have recently demonstrated that invasive melanoma cells are capable of disrupting the brain endothelial barrier integrity. This was shown using ECIS biosensor technology, which revealed rapid disruption via the paracellular junctions. In this paper, we demonstrate that melanoma cells secrete fact...

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Bibliographic Details
Main Authors: Akshata Anchan, Olivia Martin, James J. W. Hucklesby, Graeme Finlay, Rebecca H. Johnson, Laverne D. Robilliard, Simon J. O’Carroll, Catherine E. Angel, E Scott Graham
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
brain endothelial cells
ECIS technology
cytokine profiling
metastasis
TGFβ
Online Access:https://www.mdpi.com/1422-0067/21/21/8193

Internet

https://www.mdpi.com/1422-0067/21/21/8193

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