Increasing the Hydrophobic Component of Poloxamers and the Inclusion of Salt Extend the Release of Bupivacaine from Injectable In Situ Gels, While Common Polymer Additives Have Little Effect

Increasing the Hydrophobic Component of Poloxamers and the Inclusion of Salt Extend the Release of Bupivacaine from Injectable In Situ Gels, While Common Polymer Additives Have Little Effect

Various strategies have been applied to reduce the initial burst of drug release and sustain release from poloxamer-based thermoresponsive gels. This work focussed on investigating different formulation approaches to minimise the initial burst of release and sustain the release of the small hydrophi...

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Bibliographic Details
Main Authors: Hani Abdeltawab, Darren Svirskis, Andrew G. Hill, Manisha Sharma
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Gels
Subjects:
poloxamers
bupivacaine hydrochloride
sustained drug release
burst release
additive polymer
physical blending
Online Access:https://www.mdpi.com/2310-2861/8/8/484

Internet

https://www.mdpi.com/2310-2861/8/8/484

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