NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

Increases in reactive oxygen species (ROS) and decreases in nitric oxide (NO) have been linked to vascular dysfunction during diabetic retinopathy (DR). Diabetes can reduce NO by increasing ROS and by increasing activity of arginase, which competes with nitric oxide synthase (NOS) for their commons...

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Bibliographic Details
Main Authors: Modesto Rojas, Tahira Lemtalsi, Haroldo A. Toque, Zhimin Xu, David Fulton, Robert William Caldwell, Ruth B. Caldwell
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Antioxidants
Subjects:
diabetic retinopathy
retina
endothelial cell
oxidative stress
NOX2/NADPH oxidase 2
NO
NOS
arginase 1
senescence associated β-galactosidase
Online Access:http://www.mdpi.com/2076-3921/6/2/43

Internet

http://www.mdpi.com/2076-3921/6/2/43

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