Exogenous 8-Hydroxydeoxyguanosine Attenuates PM<sub>2.5</sub>-Induced Inflammation in Human Bronchial Epithelial Cells by Decreasing NLRP3 Inflammasome Activation

Exogenous 8-Hydroxydeoxyguanosine Attenuates PM<sub>2.5</sub>-Induced Inflammation in Human Bronchial Epithelial Cells by Decreasing NLRP3 Inflammasome Activation

Particulate matter 2.5 (PM<sub>2.5</sub>) induces lung injury by increasing the generation of reactive oxygen species (ROS) and inflammation. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflamma...

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Bibliographic Details
Main Authors: Jihye Bang, Kuk Hui Son, Hye-Ryeon Heo, Eunsook Park, Hyun-Jeong Kwak, Kyung-Ok Uhm, Myung-Hee Chung, Young-Youl Kim, Hyun Joung Lim
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
particulate matter 2.5
lung injury
reactive oxygen species
8-hydroxydeoxyguanosine
NLRP3 inflammasome
Online Access:https://www.mdpi.com/2076-3921/12/6/1189

Internet

https://www.mdpi.com/2076-3921/12/6/1189

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