Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE<sub>2</sub> Induced by Silica Nanoparticles

Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE<sub>2</sub> Induced by Silica Nanoparticles

The risk of lung exposure to silica nanoparticles (SiNPs) and related lung inflammatory injury is increasing with the wide application of SiNPs in a variety of industries. A growing body of research has revealed that cyclooxygenase (COX)-2/prostaglandin E<sub>2</sub> (PGE<sub>2<...

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Bibliographic Details
Main Authors: Yan-Jyun Lin, Chien-Chung Yang, I-Ta Lee, Wen-Bin Wu, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
silica nanoparticles
COX-2
PGE<sub>2</sub>
alveolar epithelial cells
ROS
FoxO1
Online Access:https://www.mdpi.com/2227-9059/11/10/2628

Internet

https://www.mdpi.com/2227-9059/11/10/2628

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