Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report

Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report

Abstract Background Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carcinoma. However, a small subset of SCs demonstrates ag...

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Bibliographic Details
Main Authors: Kensuke Suzuki, Hiroshi Harada, Masayuki Takeda, Chisato Ohe, Yoshiko Uemura, Akihiko Kawahara, Shunsuke Sawada, Akira Kanda, Bhaswati Sengupta, Hiroshi Iwai
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Medical Genomics
Subjects:
Secretory carcinoma
Salivary gland
High-grade transformation
Next-generation sequencing
ETV6-NTRK3
Entrectinib
Online Access:https://doi.org/10.1186/s12920-022-01155-6

Internet

https://doi.org/10.1186/s12920-022-01155-6

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