Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head–Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Free Assay

Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head–Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Free Assay

Using next-generation sequencing (NGS), we investigated DNA mutations in the plasma tumor cell-free circulating DNA (ctDNA) of 38 patients with inoperable squamous cell head neck cancer (SCHNC) before and after the completion of chemoradiotherapy (CRT). Baseline mutations of the <i>TP53</i&...

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Bibliographic Details
Main Authors: Michael I. Koukourakis, Erasmia Xanthopoulou, Ioannis M. Koukourakis, Sotirios P. Fortis, Nikolaos Kesesidis, Christos Kakouratos, Ioannis Karakasiliotis, Constantin N. Baxevanis
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Current Oncology
Subjects:
head neck cancer
radiotherapy
ctDNA
NGS
TP53
gene mutations
Online Access:https://www.mdpi.com/1718-7729/30/10/643

Internet

https://www.mdpi.com/1718-7729/30/10/643

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