PBPK Modeling of Azithromycin Systemic Exposure in a Roux-en-Y Gastric Bypass Surgery Patient Population

In this investigation, PBPK modeling using the Simcyp<sup>®</sup> Simulator was performed to evaluate whether Roux-en-Y gastric bypass (RYGB) surgery impacts the oral absorption and bioavailability of azithromycin. An RYGB surgery patient population was adapted from the published literat...

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Bibliographic Details
Main Authors: Suvarchala Kiranmai Avvari, Jaclyn A. Cusumano, Vamshi Krishna Jogiraju, Pooja Manchandani, David R. Taft
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/15/11/2520