Adaptive designs in critical care trials: a simulation study

Adaptive designs in critical care trials: a simulation study

Abstract Background Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care trials remains limited. A better under...

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Bibliographic Details
Main Authors: W. Li, V. Cornelius, S. Finfer, B. Venkatesh, L. Billot
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Medical Research Methodology
Subjects:
Adaptive design
Critical care
Interim monitoring
Interim analysis
Group sequential design
Bayesian
Online Access:https://doi.org/10.1186/s12874-023-02049-6

Internet

https://doi.org/10.1186/s12874-023-02049-6

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