AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

Neuroblastoma is the most common extracranial solid tumor of childhood, with heterogeneous clinical manifestations ranging from spontaneous regression to aggressive metastatic disease. The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that senses plasmatic fluctuation in the...

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Bibliographic Details
Main Authors: Eliana Gonçalves-Alves, Marta Garcia, Carlos J. Rodríguez-Hernández, Soledad Gómez-González, Rupert C. Ecker, Mariona Suñol, Oscar Muñoz-Aznar, Angel M. Carcaboso, Jaume Mora, Cinzia Lavarino, Silvia Mateo-Lozano
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
neuroblastoma
calcium-sensing receptor
calcimimetic
cinacalcet
AC-265347
biased signaling
Online Access:https://www.mdpi.com/1422-0067/23/8/4323

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https://www.mdpi.com/1422-0067/23/8/4323

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