Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology

Alzheimer’s disease (AD) is an incurable neurodegenerative disorder in which dysfunction and loss of synapses and neurons lead to cognitive impairment and death. Accumulation and aggregation of neurotoxic amyloid-β (Aβ) peptides generated via amyloidogenic processing of amyloid precursor protein (AP...

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Bibliographic Details
Main Authors: Grant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell adhesion molecule (CAM)
Alzheimer’s disease
amyloid precursor protein (APP)
amyloid-beta
immunoglobulin superfamily
integrin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.969547/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.969547/full

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