Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones

Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones

Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The...

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Bibliographic Details
Main Authors: Babak Heidary Alizadeh, Mohsen Vosooghi, Mehdi Khoobi, Azita Javidnia, Fatemeh Panah, Maliheh Safavi, Sussan Ardestani, Abass Shafiee
Format: Article
Language:English
Published: Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2010-12-01
Series:Iranian Journal of Chemistry & Chemical Engineering
Subjects:
chromane
aldol reaction
cytotoxicity
chromanone
glyasperin analogues
Online Access:http://www.ijcce.ac.ir/article_6486_852e7995780b7fb8bf5c5ad9acab058e.pdf

Internet

http://www.ijcce.ac.ir/article_6486_852e7995780b7fb8bf5c5ad9acab058e.pdf

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