Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

Merkel cell polyomavirus (MCV) and high-risk human papillomavirus (HPV) are human tumor viruses that cause Merkel cell carcinoma (MCC) and oropharyngeal squamous cell carcinoma (OSCC), respectively. HPV E7 and MCV large T (LT) oncoproteins target the retinoblastoma tumor suppressor protein (pRb) thr...

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Bibliographic Details
Main Authors: Michelle Khattri, Yutaka Amako, Julia R. Gibbs, Joseph L. Collura, Reety Arora, Alexis Harold, Meng Yen Li, Paul W. Harms, Elena Ezhkova, Masahiro Shuda
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Tumour Virus Research
Subjects:
Merkel cell polyomavirus
Merkel cell carcinoma
Human papillomavirus
Oropharyngeal squamous cell carcinoma
Enhancer of zeste homolog 2
EZH2 methyltransferase-independent function
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679023000113

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http://www.sciencedirect.com/science/article/pii/S2666679023000113

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