Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans

Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans

Acetylcholine (ACh) receptors (AChR) regulate neural circuit activity in multiple contexts. In humans, mutations in ionotropic acetylcholine receptor (iAChR) genes can cause neurological disorders, including myasthenia gravis and epilepsy. In Caenorhabditis elegans, iAChRs play multiple roles in the...

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Bibliographic Details
Main Authors: Katherine A. McCulloch, Yingchuan B. Qi, Seika Takayanagi-Kiya, Yishi Jin, Salvatore J. Cherra III
Format: Article
Language:English
Published: Oxford University Press 2017-07-01
Series:G3: Genes, Genomes, Genetics
Subjects:
acetylcholine receptor
sphingosine kinase/sphk-1
major facilitator superfamily domain (MFSD) proteins
acetylcholine transporter
unc-17
lipid
seizure
epilepsy
locomotion
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.042598

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http://g3journal.org/lookup/doi/10.1534/g3.117.042598

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