Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor regression in up to 50% or more of patients with unresectable metastatic melanoma. However, current methods to expand melanoma TIL, especially the "rapid expansion protocol" (REP) were not designed to...

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Bibliographic Details
Main Authors: Jessica Ann Chacon, Richard C Wu, Pariya Sukhumalchandra, Jeffrey J Molldrem, Amod Sarnaik, Shari Pilon-Thomas, Jeffrey Weber, Patrick Hwu, Laszlo Radvanyi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3613355?pdf=render

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http://europepmc.org/articles/PMC3613355?pdf=render

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