Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

Abstract Background Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages of the disease. Thus, immunosuppression is the goal standard for the inflammatory stage, and novel remyelination therapies are pursued...

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Bibliographic Details
Main Authors: Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza, Eduardo Muñoz
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Cannabinoids
PHDs
HIF-1α
VEGF
EPO
Online Access:http://link.springer.com/article/10.1186/s12974-018-1103-y

Internet

http://link.springer.com/article/10.1186/s12974-018-1103-y

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