Cu(II)-Mediated direct 18F-dehydrofluorination of phosphine oxides in high molar activity

Cu(II)-Mediated direct 18F-dehydrofluorination of phosphine oxides in high molar activity

Abstract Background The 18F/19F-isotope exchange method employing P(V)-centered prosthetic groups demonstrates advantages in addressing mild one-step aqueous 18F-labeling of peptides and proteins. However, the molar activity (Am) achieved through isotope exchange remains relatively low, unless emplo...

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Bibliographic Details
Main Authors: Xiaoqun Tang, Shengji Lv, Zhaobiao Mou, Xia Liu, Zijing Li
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
18F-Labeling
Dehydrofluorination
Cu(II)
Phosphine oxide
Molar activity
Online Access:https://doi.org/10.1186/s41181-023-00234-y

Internet

https://doi.org/10.1186/s41181-023-00234-y

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