PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

CD4+ Th cells play a key role in orchestrating immune responses, but the identity of the CD4+ Th cells involved in the antitumor immune response remains to be defined. We analyzed the immune cell infiltrates of head and neck squamous cell carcinoma and colorectal cancers and identified a subset of C...

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Bibliographic Details
Main Authors: Rebekka Duhen, Olivier Fesneau, Kimberly A. Samson, Alexandra K. Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D. Weinberg, Thomas Duhen
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-06-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Oncology
Online Access:https://doi.org/10.1172/JCI156821

Internet

https://doi.org/10.1172/JCI156821

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