Inhibition of Matrix Metalloproteinases and Cancer Cell Detachment by Ru(II) Polypyridyl Complexes Containing 4,7-Diphenyl-1,10-phenanthroline Ligands—New Candidates for Antimetastatic Agents

Inhibition of Matrix Metalloproteinases and Cancer Cell Detachment by Ru(II) Polypyridyl Complexes Containing 4,7-Diphenyl-1,10-phenanthroline Ligands—New Candidates for Antimetastatic Agents

Primary tumor targeting is the dominant approach in drug development, while metastasis is the leading cause of cancer death. Therefore, in addition to the cytotoxic activity of a series of Ru(II) polypyridyl complexes of the type [Ru(dip)<sub>2</sub>L]<sup>2+</sup> (dip: 4,7-...

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Bibliographic Details
Main Authors: Przemysław Gajda-Morszewski, Ilona Gurgul, Ewelina Janczy-Cempa, Olga Mazuryk, Michał Łomzik, Małgorzata Brindell
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
ruthenium(II) polypyridyl complexes
matrix metalloproteinases
inhibition of MMP-2 and MMP-9
cell adhesion properties
cytotoxicity
cell detachment
Online Access:https://www.mdpi.com/1424-8247/14/10/1014

Internet

https://www.mdpi.com/1424-8247/14/10/1014

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