Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study

Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study

Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore t...

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Bibliographic Details
Main Authors: Mohammad Ashrafuzzaman, Roger E. Koeppe, Olaf S. Andersen
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
lipid intrinsic curvature
elasticity
amphiphiles
bilayer-mediated regulation
gramicidin channel
alamethicin channel
Online Access:https://www.mdpi.com/1422-0067/25/5/2758

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https://www.mdpi.com/1422-0067/25/5/2758

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