Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

Summary: Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 in endothelial cells (ECs), pointing...

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Bibliographic Details
Main Authors: Evgenia Fadzeyeva, Cassandra A.A. Locatelli, Natasha A. Trzaskalski, My-Anh Nguyen, Megan E. Capozzi, Branka Vulesevic, Nadya M. Morrow, Peyman Ghorbani, Antonio A. Hanson, Ilka Lorenzen-Schmidt, Mary-Anne Doyle, Richard Seymour, Elodie M. Varin, Morgan D. Fullerton, Jonathan E. Campbell, Erin E. Mulvihill
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Biological sciences
Physiology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223008258

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http://www.sciencedirect.com/science/article/pii/S2589004223008258

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