Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

The dopamine D2/D3 receptor (D<sub>2</sub>R/D<sub>3</sub>R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D<sub>3</sub>R over D<sub>2</sub>R is attractive because of D<sub>3</s...

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Bibliographic Details
Main Authors:	Pramisha Adhikari, Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy H. Newman, Hideaki Yano, Lei Shi
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Biomolecules
Subjects:	dopamine D3 receptor dopamine D2 receptor bitopic ligand biased agonism functional selectivity subtype selectivity
Online Access:	https://www.mdpi.com/2218-273X/11/4/570

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