Circulating syndecan-1 and glypican-4 predict 12-month survival in metastatic colorectal cancer patients

Circulating syndecan-1 and glypican-4 predict 12-month survival in metastatic colorectal cancer patients

Cell surface syndecans and glypicans play important roles in the development and prognosis of colorectal cancer (CRC). Their soluble forms from proteoglycan shedding can be detected in blood and have been proposed as new prognostic biomarkers in several cancer entities. However, studies on circulati...

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Bibliographic Details
Main Authors: Axel Muendlein, Luciano Severgnini, Thomas Decker, Christine Heinzle, Andreas Leiherer, Kathrin Geiger, Heinz Drexel, Thomas Winder, Patrick Reimann, Frank Mayer, Christoph Nonnenbroich, Tobias Dechow
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
proteoglycans
shedding
syndecan-1 (SDC1)
glypican-4
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1045995/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1045995/full

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