Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

Background: The relationship between genotype and phenotype is governed by numerous genetic interactions (GIs), and the mapping of GI networks is of interest for two main reasons: 1) By modelling biological robustness, GIs provide a powerful opportunity to infer compensatory biological mechanisms vi...

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Bibliographic Details
Main Authors: Sathish Periyasamy, Pierre Youssef, Sujit John, Rangaswamy Thara, Bryan J. Mowry
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Genetics
Subjects:
epistasis
schizophrenia
genetic interaction analysis
GWAS
hub genes
systems biology
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1301150/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1301150/full

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