Deletion of exons 2 and 3 from Actb and cell immortalization lead to widespread, β-actin independent alterations in gene expression associated with cell cycle control

Deletion of exons 2 and 3 from Actb and cell immortalization lead to widespread, β-actin independent alterations in gene expression associated with cell cycle control

The cytoplasmic actin proteins, β- and γ-actin, are 99% identical but thought to perform non-redundant functions. The nucleotide coding regions of cytoplasmic actin genes, Actb and Actg1, are 89% identical. Knockout (KO) of Actb by Cre-mediated deletion of first coding exons 2 and 3 in mice is embry...

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Bibliographic Details
Main Authors: Lauren J. Sundby, William M. Southern, Jiao Sun, Xiaobai Patrinostro, Wei Zhang, Jeongsik Yong, James M. Ervasti
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:European Journal of Cell Biology
Subjects:
β-actin
Actb
actin
cell cycle
RNA-sequencing
proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000141

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http://www.sciencedirect.com/science/article/pii/S0171933524000141

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